On June 19th, The European Institute, in partnership with Sanofi, convened a meeting of the Transatlantic Roundtable on Innovation and Research in Boston, Massachusetts. Held on the margins of the BIO 2012 Convention, the meeting focused on the challenges facing the sustainability of biomedical research at a time of potent scientific promise and increasingly limited financial resources. Christopher Viehbacher, Chief Executive Officer at Sanofi, opened and moderated the discussion with Dr. Elias Zerhouni, President of Global Research and Development at Sanofi; Dr. Arnd Hoeveler, Head of Unit for Advanced Therapies and Systems Medicine for DG Research and Innovation at the European Commission; Dr. Vicki Seyfert-Margolis, Senior Advisor for Science and Innovation in the Office of the Chief Scientist at the U.S. Food and Drug Administration; and Robert Wells, Head of the Biotechnology Unit in the Directorate for Science and Technology at the OECD.